I had either the same or a similar issue. I double clicked HyperSpin.exe and I could see the background process (HyperSpin (32 bit)) running in the Task Manager's Processes tab, but no window would ever come up.
I had placed sxs.dll in my root directory as recommended here: https://hyperspin-fe.com/forums/topic/42440-hyperspin-not-loading/
When right clicking HyperSpin.exe and going to Properties, I had checked "Run this program as an administrator" in the compatibility tab.
I had turned off Windows Defender *in the control panel*, and added an exception for HyperSpin.exe anyway even though that shouldn't matter with Defender turned off.
So I still had the issue with all of that done and I decided to double check myself. I used the Windows search blank next to the start button to open Windows Defender settings again expecting to be take to the Control Panel again, but instead it offered a different window. This time it launched the Windows Defender Firewall with Advanced Security window. It said Defender was turned on, so I turned it off here as well. After that, it FINALLY WORKED! I just double clicked HyperSpin.exe and the program launched in full screen.
So if there are any steps I did here that you have not done, please give them a try! Good luck.