These fixes have been rolling for years, mostly when Windows 10 was released with its subsequent updates. The .dll fix doesn't seem to work for everyone and there's the Defender issue, which is probably the main reason why most users have been facing issues starting the frontend. Since HS also relies on flash, which has been discontinued for years, it could be one of the reasons why it's flagged as a potential risk, but I'm not a developer, thus, I'm not sure.
As for suggestions, depending on how you use your PC, if it's dedicated to gaming, you can either install a Windows version that won't update, and will only receive important security updates, or make it offline entirely, deactivating or making sure the anti-virus won't block its functionality.
Is Hyperspin your only option? Have you tried another frontend, which is currently supported? I know there are many free options that have modern features, making it much easier to setup your systems.
Hyperspin's and its community's heyday ended in 2018 at best, many talented people came and went their ways, it's a legacy and in my view, many other frontends owe a great deal to it, thousands of logos, box arts, databases, and Emumovies is a branch of Hyperspin and vice-versa, which feeds even more other frontends media overall.
If, for some reason, you decide to stick to Hyperspin, make sure you understand that its development ceased for many years and these fixes may or may not work forever.
Let's face it, it's old, it runs at 1024x768, closed source and it's not like there aren't modern options.
RocketLauncher development also ceased, few users are keeping modules working.
I see how keeping Hyperspin working makes sense for very old users which has a working HS setup and put a lot of effort on it, however, any newer users are advised that your mileage will be way easier and more comfortable with a current, more modern option, that won't alarm your anti-virus and won't need fixes to work on current OSes.